News

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LumiThera and LightSite I Making Waves

LIGHTSITE I

LumiThera Inc is a medical device company currently focused on developing a non-invasive Photobiomodulation therapy for ocular (eye) disorders and disease. Their pilot product LightSite I provided great results after their first clinical trial for the ‘treatment of dry age-related macular degeneration (AMD) utilizing its LT-300 Light Delivery System’. 

The results from the clinical trial was presented at the 2018 Association for Research in Vision and Ophthalmology (ARVO) annual conference by members of the LumiThera investigation team. The team consisted of: Marion Munk, MD, PhD, Department of Ophthalmology/Bern Photographic Reading Center and Managing Director, Bern Photographic Reading Center, University Hospital Bern. 

“LumiThera PBM treatment demonstrated reductions in central drusen volume over the course of the one-year study versus the sham treatment with statistical significance at one year, (p = 0.05).  Drusen is the hallmark pathology of dry AMD and is an important proinflammatory mediator and marker for disease progression,” says Dr. Munk.

“Results from the LIGHTSITE I study following treatment with a multi-wavelength PBM treatment demonstrated clinical improvements in vision outcome measures providing a strong foundation for initial therapy as well as the need for follow-up maintenance therapy,” stated Samuel Markowitz, M.D., Co-Principal Investigator, Department of Ophthalmology and Vision Sciences, University of Toronto.  “The PBM therapy was most beneficial in dry AMD patients immediately following the completion of the treatment sessions. Contrast sensitivity or detailed vision was significantly improved throughout the year. Retreatments at a 6 month interval were performed to maintain clinical benefits.”

LumiThera Light Site  LT-300 LED ophthalmologic instrument station provides a multi-wavelength approach to treating ocular disease.

LumiThera Light Site
LT-300 LED ophthalmologic instrument station provides a multi-wavelength approach to treating ocular disease.

“We are excited by the completion of the LIGHTSITE I trial and seeing the benefits in both clinical outcomes and drusen pathology,” stated Clark Tedford, Ph.D., LumiThera President and CEO. “The LT-300 Light Delivery System performance was excellent throughout the clinical trial and patients provided positive feedback from their PBM treatment experience over the course of a year. This foundational data will accelerate our learning to develop options to treat complicated degenerative eye disease, where patient options are limited. The results demonstrate that the therapy is both a safe and effective treatment for early stage dry AMD patients. The current trial results will be used to refine the upcoming multi-center clinical trials expected to start initially in Europe.”

“LumiThera’s LIGHTSITE I data is the first prospective, sham controlled, double-masked, pilot clinical dry AMD study with PBM,” says Dr. Robert Devenyi, Co-Principal Investigator, Ophthalmologist-in-Chief and Director of Retinal Services, UHN, University of Toronto. “The results show PBM using the LT-300 device can improve Visual Acuity and Contrast Sensitivity as vision endpoints for dry AMD patients to counteract the degradation in vision that this disabling disease brings.”

The pilot study consisted of 30 people and was partially funded by a grant from a Small Business Innovation Research fund, awarded to LumiThera from the National Institute of Health and the National Eye Institute.  The clinical trial tested each person’s vision and examined disease pathology in the eye, following PBM treatments for up to one year.

Visit the Company’s website at www.lumithera.com.

About LumiThera Inc.

LumiThera is a clinical-stage medical device company focused on treating people affected by ocular disorders and diseases including dry age-related macular degeneration, a leading cause of blindness in adults over 65. The Company is a leader in the use of Photobiomodulation for treatment of acute and chronic ocular diseases and disorders. The Company is developing the office-based LT-300 Light Delivery System to be used by ophthalmologists and other eye specialists as non-invasive medical treatments.

Important to note: The LT-300 is not yet approved for use by the Food & Drug Administration in the USA. The device has also not yet been granted a CE Mark by a Notified Body for commercial use outside of the USA.

The LT-300 LED ophthalmologic instrument station is designed to provide a multi-wavelength approach to treating ocular disease.

Working research and clinical units are being built to support ongoing research and development activities.

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Condolences to the Family of Artist Hariton Pushwagner

Artist Pushwagner has passed away

Terje Brofos, better known as Hariton Pushwagner, was a Norwegian Pop Artist. His art is of a colourful and spiritual nature, and traveled extensively during his life in order to gather his own personal style.

Pushwagner at Bærum Kunstforening,June 2014 in Sandvika, Norway.

Pushwagner at Bærum Kunstforening,June 2014 in Sandvika, Norway.

Mr Christian Barman, of Eyekandi Ltd, has one of his iconic pieces up on the walls of the Eyekandi Headquarters in Chiang Mai, Thailand.

Unfortunately Mr Pushwagner was recently diagnosed with lung cancer and died at the Diakonhjemmet Hospital on 24 April 2018, at the age of 77.

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Dottir on the Front Cover: Bolig Magasinet

Dottir Nordic Design

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Eyekandi has partnered with many a creative mind.

In particular we have partnered with many Nordic creatives and designers, one being, Dottir Nordic Design.

Today they were featured on the front page of Denmark’s largest housing magazine, Bolig Magasinet! Their exquisite attention to detail was captured in these pictures of a beautifully decorated home.

BOLIGMASINET Dottir Nordic Design     BOLIGMASINET Dottir Nordic Design BOLIGMASINET Dottir Nordic Design

More About Dottir

“The creative thinking behind all DOTTIR products is nurtured by the contrasts of Nordic living, with its dark cold winters and bright warm summer nights, it’s deep silent lakes and strong ocean streams.
All products express this arabesque of sweet wildness which gives a versatile and creative expression. We are in contrast to the minimalistic Nordic expression and see ourselves as frontrunners of the next Nordic Design movement. In short. Less is a bore.”

Shop at their online store or contact them directly to decorate your home with some Nordic expression.

Contact Eyekandi if you’re interested in getting things made, we’re your supply-chain specialists in China and Thailand.

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Pre & Post Workout LLLT and BBS with Eyekandi Life Tech

Bio Hack your Workout with Eyekandi

At our Eyekandi Life Tech headquarters in Chiang Mai Thailand, we take bio-hacking seriously. If there’s a way to increase results we will generally look into it. When theres a way to increase our performance in terms of our BBS workout? Well now, we’re pretty serious.

With the development and launch of our new app, BBS (Body By Science App available for iOS iPhone/iPad), as well as the research we are doing with LLLT (Low Level Light Therapy), Photo-bio-modulation, and NIR (Near Infrared), we have seen incredible results with ourselves. We have recently come across research which has been going on in the background for a number of years by Chiropractors and Sports Science enthusiasts. This backs our own studies and confirms what we have found:

“Combining pre and post workout LLLT can ‘ease muscle fatigue’ and reduce inflammation”

LLLT exposure either before or after fatigue reduced the post-fatigue concentrations of serum lactate and creatine kinase. The results were more pronounced when the LLLT was applied after exercise.

Based on this research, it would appear that low level laser therapy can be a valuable addition to any chiropractor’s treatment regimen to reduce muscle fatigue for those patients who regularly exercise or participate in sports.

In addition to combining LLLT with pre and post workouts, research has also shown that LLLT helps to treat some injuries to the muscles.

LLLT may ease muscle fatigue before and after workout https://www.chiroeco.com/low-level-laser-therapy-to-treat-muscle-fatigue-before-or-after-exercise/

LLLT may ease muscle fatigue before and after workout
Photograph courtesy of Chiroeco

 

Knee injuries and conditions treated by LLLT include tendonitis, bursitis, meniscus tears, runners knee/chondromalacia patella, knee joint effusion, iliotibial band syndrome, osgood schlatters disease, osteoarthritis and rheumatoid arthritis. Very low power is used with the application of LLLT and no heating of or damage to the tissue occurs. It also increases cell metabolism.

LLLT emit light in the red and infrared range. Red and infrared light infiltrate the human tissue. This is where the energy from the light is then absorbed and turned into biochemical energy. By increasing cellular energy in the treated area, LLLT is therefore speeding up the healing process and reducing inflammation and pain.

By using LLLT, Photo-bio-modulation or NIR light technology, you are reducing the impact of muscle fatigue, pain and inflammation. Therefore using LLLT before and after your BBS workout, you will have increased stamina and less chance of injury in order to receive good results.

For the geeks: here is some science

Photons, which are particles of electromagnetic energy, are emitted from the low power light. These photons enter the tissues and are absorbed in the mitochondria, which are tiny structures within the substance of each individual cell. The energy is converted to chemical energy within the cell. The permeable state of the cell membrane changes which in turn produces various physiological effects. These physiological changes affect a variety of cell types including macrophages, fibroblasts, endothelial cells and mast cells.

Absorption of light by plants is the driving force for much of the life on earth, so why not humans too?!

Give it a try and let us know how it goes!

 

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BBS resistance training App icon

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Norwegian Presence Exhibition, Milan Design Week

Eyekandi is proud to announce!

The presence of some of the Norwegian designed products we have been involved in manufacturing will be featured at the Milan Design Week!

Elementa Milan Design Week

A little bit about Elementa:

Elementa is a Norwegian producer working with designers, artists and scientists to explore new directions in the Scandinavian design tradition.

Since the startup in 2012, Elementa has helped to furnish a lot of spaces, including some of Norway’s most interesting creative workspaces. Their project list also includes several bigger projects such as The Norwegian Research Council, The Norwegian Ministry of Education, Statistics Norway (SSB) and The Norwegian Cultural Council, just to name a few.

This week we are happy to invite you to the exciting Norwegian Presence exhibition during Milan Design Week 17-22 April 2018

Elementa will launch the first products of the anticipated UT series. This includes works by Kneip Hallgeir Homstvedt, Emma Staubo & Jomi Evers – and teasers of upcoming projects with Anderssen & Voll, Haffner Architects and bowmaker Håkon Fellberg.

Ki, a minimalist lamp Norwegian designed manufactured by Eyekandi

The Path Leads UT: The winter season can seem unending in Norway. Hallgeir Homstvedt has designed the Ki, a Norwegian Designed minimalist lamp that will keep both your plants and yourself happy and thriving the whole year.

 

The Elementa UT project is a series of objects. These are developed with Scandinavian designers and artists to remind us that we are always in nature. Even when indoors.

Elementa / Norwegian Presence
Via Tortona 31 Milan
17-22 April
www.norwegianpresence.no

If you’re going to the exhibition, look out for these beautiful designs.

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Infrared Sauna Light Spectrum and Benefits

The Infrared Light Spectrum and Dave Asprey

We’ve had a great interest in the way Mr Dave Asprey from the Bulletproof Blog has shown enthusiasm for the various spectrums of Infrared Light Saunas and how to use them to maximise performance and life. We thought it a great idea to keep sharing this research with our readers as well.

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The Eyekandi Life Tech Team are developing some cutting edge tech within this field of Infrared Light, so watch this space!

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Why choose to Sauna, INFRARED infused

Saunas can quickly and effectively help you get back to feeling amazing again.  Sauna therapy has been around for centuries as a way to detoxify your body, but did you know that full spectrum infrared saunas can go even further by heating up your body’s core to a cellular level, where most toxins are stored?

Infrared’s deep penetrating heat is what most effectively stimulates metabolic activity, which in turn triggers the release of stored toxins through sweat, as well as through the liver and kidneys.

Have you ever had a thought about this: the reason why your body goes into fever conditions when you’re sick – a hotter body increases metabolic activity, kills unwanted intruders, and stimulates the release of toxins.  Viruses and sometimes even tumour cells can be destroyed by heat.

Highly emissive far infrared saunas help recreate your body’s fever-like response condition but raising your core body temperature, to make you feel even better inside and out.

Below are some of the researched benefits of the infrared spectrum on the body:

Far Infrared:

detoxification

lowering of blood pressure

relaxation

Mid Infrared:

improved circulation

weight loss

pain relief

Near infrared:

cell health (immune system benefit)

healing of wounds and abrasions

anti-aging benefits

oxygenation of tissue cells

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Photo Courtesy of Sunlighten, a Sauna with a range of infrared light spectrums

If you have taken the plunge and are already using an infrared sauna for health benefits, the SINGLE MOST important factor to consider is, heater emissivity (the ability of a surface to emit radiant energy).

‘high emissivity equals high quality and quantity of infrared light.’

Using the infrared light for a healthy lifestyle means using it regularly. Give it a try if you arent doing it already, and let us know how you go!

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Light Hacking and Life Hacking? Credit to the Bulletproof Blog!

Life Hacking and The Bulletproof Blog

According to the infamous Mr Dave Asprey of the Bulletproof blog and lifestyle, there are a couple of ‘Light Hacks’ to create a better mood, better energy, AND better performance. As always, here at Eyekandi, when it comes down to increasing performance and hacking things, we’re all over it.

And you should be too!

For convenience to our readers, and relevance to our current research and interest in Photobiomodulation and LLLT, we will be focussing on Mr Asprey’s Light Hacks from 7,8 & 10.  Just FYI, his Light Hacks from 1-6 and 9, include the importance of UV rays, vitamin D, light and your eyes, darkness, photon waves and ‘junk light’. And if you’re interested in them, click here to see the full article on the Bulletproof Blog.

Mr Dave Asprey Bulletproof Blog Light Hacking

Mr Dave Asprey of the Bulletproof Blog

Light Hack #7: Use red light for pain, inflammation, and skin

Red light is amazing at recharging your mitochondria. Red light can also stimulate DNA and RNA synthesis, activate the lymphatic system and increase blood flow, which is good for carrying waste from the body and repairing damaged tissue. It can even decrease inflammation and swelling, all the way down to deep tissue.

That means more energy, less pain, and things like faster wound healing. Red light donates photons to your mitochondria via molecules called cytochromes, which allows them to make even more ATP for energy. This provides you with steady energy all day and better sleep at night.

How to use it: Install red lights in and around your home and use them in the early morning, at night, and therapeutically for an increase in mitochondrial function and collagen production.

For collagen synthesis, a couple minutes every day in front of a red light could significantly improve your skin’s tone, texture, redness, and signs of wrinkles and fine lines. You can also find medical-grade LLLT practitioners for a heavier dose of light.

 

Light Hack #8: Low-Level Light Therapy (LLLT)

Low-level light therapy or LLLT is like a more intense version of sitting under a red light. This is a cold laser that concentrates light to one area on your body.

Athletes use LLLT for better athletic performance, probably because it increases strength and speeds up muscle recovery. It also helps to heal infections post-surgery, relieves chronic and acute pain (especially in your joints), and decreases inflammation. LLLT increases energy by stimulating mitochondria and boosting ATP production and blood flow. And it contributes to healthy skin by healing scars and burns and decreasing UV damage. Lasers shrink nerve inflammation, so putting an LLLT 3-4 inches above your belly button, right below the rib cage, can help with stomachaches and nausea, as well as an inflamed gut.

How to use it: You can find a practitioner that uses LLLT or buy one yourself. The medical-grade lasers are pretty expensive, but consumer-grade LLLT units run anywhere from a couple hundred to a couple thousand dollars. Eyekandi Life Tech is on the brink of bringing one of these products out into the market.

WATCH THIS SPACE
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Light Hack #10: Add infrared light

Sunlight has infrared light, but you won’t get any of it from indoor lighting. You can’t see infrared light, but you can feel it; it is experienced as heat, and it supercharges your mitochondria.

You can get infrared light, which triggers even more energy production from your mitochondria in your eyes and skin, with a healthy dose of sun exposure, in incandescent bulbs (in very small amounts), or with an infrared sauna. Increased mitochondrial function, again, is going to increase blood flow, which is great for nutrient and oxygen transport and also speeds up detox pathways. This is why people are obsessed with infrared saunas.

How to use it: Switch all the bulbs in your house to incandescent, which emit a small amount of infrared. Find an infrared sauna with full-spectrum, near-infrared light. You also want to find one that emits low to no non-native EMFs (electric magnetic fields).

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The Good Inhaled Nanoparticles – WHAAT??

Nanoparticles

At Eyekandi, we are very open minded about ‘expanding our mind’s capacities’ within a framework of legalities. When articles are written about inhaled nanoparticles and therapeutic peptides, we’re all over it, and want to share it with you all too.

 

Dr. Derek Lowe is a chemistry blogger and medicinal chemist working on preclinical drug discovery, previously as a Research Fellow at Vertex Pharmaceuticals. Read this article where he comments on the 'good' inhaled nanoparticles!

Dr. Derek Lowe is a chemistry blogger and medicinal chemist working on preclinical drug discovery, previously as a Research Fellow at Vertex Pharmaceuticals. Read this article where he comments on the ‘good’ inhaled nanoparticles!

 

‘Never give up on drug delivery ideas’ – that’s one of the big points Mr Derek Lowe gets out of this paper. The authors, part of a multi-centre team from sites in Italy and Germany, have previously shown that calcium phosphate nanoparticles could be a good carrier for delicate cargo such as microRNAs.

MicroRNAs

MicroRNAs are small non-coding RNA molecules (containing about 22 nucleotides) which can be found in plants, animals and some viruses, that functions in RNA silencing and post-transcriptional regulation of gene expression…

Such things tend to get degraded pretty quickly in the bloodstream; our bodies do not particularly want lots of nucleic acid strands floating around between the organs. Therapeutic peptides suffer from similar disadvantages – anyone working on one usually ends up spending lots of time modifying the original peptide structure to keep it around long enough in the body in order for it to be effective.

This paper shows that the CaP nanoparticles are effective carriers of therapeutic peptides, but what’s alarming is that they show them working through inhalation. What gave them this idea? Air pollution! Here is an excerpt from the paper so you can see what we’re talking about:

The rationale for the use of this unconventional administration route for targeting of the heart is based on the concepts that (i) during respiration the oxygenated blood moves from the pulmonary circulation first to the heart via the pulmonary vein and (ii) combustion-derived nanoparticles and ultrafine particulates inhaled through polluted air were recently shown by us (16) and others (17) to be present in the heart and causally associated with cardiac arrhythmia and dysfunction, suggesting that inhaled nanoparticles are deposited in the heart. Furthermore, CaPs can protect peptides from immediate enzymatic degradation and, because of their negative surface charge, provide cellular permeability via the membrane internalization.

It’s not over yet

There are a lot of issues which need to be addressed still, as the paper itself makes pretty clear. One thing is for sure, as with all inhalation routes, you have to wonder about the variation in lung function, both in healthy and diseased patients. Long-term studies of the effects on lung tissue would be needed, as well as a lot more pharmocokinetic work in general.

The Eyekandi team are currently expanding their horizons and knowledge about various interesting topics, and we’d appreciate your thought!

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1903: The Nobel Prize for Light Radiation

A Nobel Prize Winner for the use of Light Radiation

In 1903, the Nobel Prize in Physiology or Medicine was granted to Mr Niels Ryberg Finsen to acknowledge his contribution to the treatment of diseases, especially lupus vulgaris also known as tuberculosis luposa, with the use of concentrated light radiation.

Tuberculosis luposa

Tuberculosis luposa are painful skin lesions with a nodular appearance. These are found most often on the face: around the nose, eyelids, lips, cheeks, ears and neck. It is the most common Mycobacterium tuberculosis skin infection. The lesions may ultimately develop into disfiguring skin ulcers if left untreated.

Mr Niels Ryberg Finsen, the Nobel Prize winner for Physiology or Medicine 1903: for the use of light radiation

Mr Niels Ryberg Finsen, the Nobel Prize winner for Physiology or Medicine 1903

Niemann–Pick disease

Mr Finsen suffered from Niemann–Pick disease. This inspired him to sunbathe and investigate the effects of light on living things.  Nieman-Pick disease is a subgroup of lipid storage disorders called sphingolipidoses. This is where harmful quantities of fatty substances, or lipids, accumulate in the spleen, liver, lungs, bone marrow, and brain.

As a result, Finsen is best known for his theory of phototherapy. According to this theory, certain wavelengths of light can have beneficial medical effects.

His most notable writings were Finsen Om Lysets Indvirkninger paa Huden (“On the effects of light on the skin”), published in 1893., and Om Anvendelse i Medicinen af koncentrerede kemiske Lysstraaler(“The use of concentrated chemical light rays in medicine”), published in 1896.

The Eykandi crew are currently developing new and innovative ways to harness the goodness from Light radiation, Photo-Bio-Modulation and Near-infrared treatments.

Watch this space and get in touch with us if you’re interested too…

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Blockchain platform in Thailand shared by local banks

The central bank in Thailand has recently disclosed that fourteen Thai banks will join hands to develop a shared trade finance platform based on blockchain technology.

Blockchain: the Banks are on board

Within the fourteen, the big four banks, Bangkok BankKrung Thai BankSiam Commercial Bank and Kasikornbank are on board and are scheduled to launch electronic letters of guarantee on a shared blockchain platform. The service will firstly be tested and come online eventually by September of this year.

The system was initially launched by Kasikornbank in collaboration with U.S. computing company IBM last July. It is built on a distributed ledger framework called Hyperledger Fabric provided by the Linux Foundation. State enterprises are already using letters of guarantee issued through the system, according to the bank.

The group would be similar to the Digital Trade Chain consortium that was formed last year by seven European banks such as Deutsche Bank and HSBC to develop a shared trade finance platform using blockchain.

“With this infrastructure sharing, banks do not need to invest on their own,” Bank of Thailand Gov. Veerathai Santiprabhob told reporters Monday. “Interoperability enhances efficiency, reduces costs in our financial sector and addresses the needs of the consumer and the business sector.”

Thai banks and companies join hands to promote a shared finance platform using blockchain technology.  Nekki Asian Review

Thai banks and companies join hands to promote a shared finance platform using blockchain technology. Nikkei Asian Review

Letters of Guarantee

The new blockchain system will digitise the documents and shorten the process to as little as 30 minutes. Previously in Thailand this was a lengthy process and sometimes took a few days to process!

Initially, the blockchain service will cover letters of guarantee issued for bidders in state-owned enterprise auctions and other domestic trading. Seven corporates, including the state-owned Electricity Generating Authority of Thailand and industrial conglomerate Siam Cement Group, are set to use the system. The companies will be able to store their suppliers’ letters of guarantee using the cloud system and obtain updated documents whenever they want.

View the original article here on the Nikkei Asian Review Website, written by YUKAKO ONO, Nikkei staff writer.

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