Tag eyekandi

The Good Inhaled Nanoparticles – WHAAT??

Nanoparticles

At Eyekandi, we are very open minded about ‘expanding our mind’s capacities’ within a framework of legalities. When articles are written about inhaled nanoparticles and therapeutic peptides, we’re all over it, and want to share it with you all too.

 

Dr. Derek Lowe is a chemistry blogger and medicinal chemist working on preclinical drug discovery, previously as a Research Fellow at Vertex Pharmaceuticals. Read this article where he comments on the 'good' inhaled nanoparticles!

Dr. Derek Lowe is a chemistry blogger and medicinal chemist working on preclinical drug discovery, previously as a Research Fellow at Vertex Pharmaceuticals. Read this article where he comments on the ‘good’ inhaled nanoparticles!

 

‘Never give up on drug delivery ideas’ – that’s one of the big points Mr Derek Lowe gets out of this paper. The authors, part of a multi-centre team from sites in Italy and Germany, have previously shown that calcium phosphate nanoparticles could be a good carrier for delicate cargo such as microRNAs.

MicroRNAs

MicroRNAs are small non-coding RNA molecules (containing about 22 nucleotides) which can be found in plants, animals and some viruses, that functions in RNA silencing and post-transcriptional regulation of gene expression…

Such things tend to get degraded pretty quickly in the bloodstream; our bodies do not particularly want lots of nucleic acid strands floating around between the organs. Therapeutic peptides suffer from similar disadvantages – anyone working on one usually ends up spending lots of time modifying the original peptide structure to keep it around long enough in the body in order for it to be effective.

This paper shows that the CaP nanoparticles are effective carriers of therapeutic peptides, but what’s alarming is that they show them working through inhalation. What gave them this idea? Air pollution! Here is an excerpt from the paper so you can see what we’re talking about:

The rationale for the use of this unconventional administration route for targeting of the heart is based on the concepts that (i) during respiration the oxygenated blood moves from the pulmonary circulation first to the heart via the pulmonary vein and (ii) combustion-derived nanoparticles and ultrafine particulates inhaled through polluted air were recently shown by us (16) and others (17) to be present in the heart and causally associated with cardiac arrhythmia and dysfunction, suggesting that inhaled nanoparticles are deposited in the heart. Furthermore, CaPs can protect peptides from immediate enzymatic degradation and, because of their negative surface charge, provide cellular permeability via the membrane internalization.

It’s not over yet

There are a lot of issues which need to be addressed still, as the paper itself makes pretty clear. One thing is for sure, as with all inhalation routes, you have to wonder about the variation in lung function, both in healthy and diseased patients. Long-term studies of the effects on lung tissue would be needed, as well as a lot more pharmocokinetic work in general.

The Eyekandi team are currently expanding their horizons and knowledge about various interesting topics, and we’d appreciate your thought!

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1903: The Nobel Prize for Light Radiation

A Nobel Prize Winner for the use of Light Radiation

In 1903, the Nobel Prize in Physiology or Medicine was granted to Mr Niels Ryberg Finsen to acknowledge his contribution to the treatment of diseases, especially lupus vulgaris also known as tuberculosis luposa, with the use of concentrated light radiation.

Tuberculosis luposa

Tuberculosis luposa are painful skin lesions with a nodular appearance. These are found most often on the face: around the nose, eyelids, lips, cheeks, ears and neck. It is the most common Mycobacterium tuberculosis skin infection. The lesions may ultimately develop into disfiguring skin ulcers if left untreated.

Mr Niels Ryberg Finsen, the Nobel Prize winner for Physiology or Medicine 1903: for the use of light radiation

Mr Niels Ryberg Finsen, the Nobel Prize winner for Physiology or Medicine 1903

Niemann–Pick disease

Mr Finsen suffered from Niemann–Pick disease. This inspired him to sunbathe and investigate the effects of light on living things.  Nieman-Pick disease is a subgroup of lipid storage disorders called sphingolipidoses. This is where harmful quantities of fatty substances, or lipids, accumulate in the spleen, liver, lungs, bone marrow, and brain.

As a result, Finsen is best known for his theory of phototherapy. According to this theory, certain wavelengths of light can have beneficial medical effects.

His most notable writings were Finsen Om Lysets Indvirkninger paa Huden (“On the effects of light on the skin”), published in 1893., and Om Anvendelse i Medicinen af koncentrerede kemiske Lysstraaler(“The use of concentrated chemical light rays in medicine”), published in 1896.

The Eykandi crew are currently developing new and innovative ways to harness the goodness from Light radiation, Photo-Bio-Modulation and Near-infrared treatments.

Watch this space and get in touch with us if you’re interested too…

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Blockchain platform in Thailand shared by local banks

The central bank in Thailand has recently disclosed that fourteen Thai banks will join hands to develop a shared trade finance platform based on blockchain technology.

Blockchain: the Banks are on board

Within the fourteen, the big four banks, Bangkok BankKrung Thai BankSiam Commercial Bank and Kasikornbank are on board and are scheduled to launch electronic letters of guarantee on a shared blockchain platform. The service will firstly be tested and come online eventually by September of this year.

The system was initially launched by Kasikornbank in collaboration with U.S. computing company IBM last July. It is built on a distributed ledger framework called Hyperledger Fabric provided by the Linux Foundation. State enterprises are already using letters of guarantee issued through the system, according to the bank.

The group would be similar to the Digital Trade Chain consortium that was formed last year by seven European banks such as Deutsche Bank and HSBC to develop a shared trade finance platform using blockchain.

“With this infrastructure sharing, banks do not need to invest on their own,” Bank of Thailand Gov. Veerathai Santiprabhob told reporters Monday. “Interoperability enhances efficiency, reduces costs in our financial sector and addresses the needs of the consumer and the business sector.”

Thai banks and companies join hands to promote a shared finance platform using blockchain technology.  Nekki Asian Review

Thai banks and companies join hands to promote a shared finance platform using blockchain technology. Nikkei Asian Review

Letters of Guarantee

The new blockchain system will digitise the documents and shorten the process to as little as 30 minutes. Previously in Thailand this was a lengthy process and sometimes took a few days to process!

Initially, the blockchain service will cover letters of guarantee issued for bidders in state-owned enterprise auctions and other domestic trading. Seven corporates, including the state-owned Electricity Generating Authority of Thailand and industrial conglomerate Siam Cement Group, are set to use the system. The companies will be able to store their suppliers’ letters of guarantee using the cloud system and obtain updated documents whenever they want.

View the original article here on the Nikkei Asian Review Website, written by YUKAKO ONO, Nikkei staff writer.

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Radiation is used to Lose Fat, Repair Mitochondria & Defend Against Cancer – Dr. Joseph Mercola Bulletproof Radio

Using Radiation To Lose Fat, Repair Mitochondria & Defend Against Cancer – Dr. Joseph Mercola

PODCAST ALERT – BULLETPROOF RADIO by Mr Dave Asprey and Dr Joseph Mercola

If you’re needing a reason to press play:

Attacking your body with radiation is one of the most efficient ways to help you get rid of fat, repair damaged mitochondria and protect yourself from the dreaded C word (cancer). Dave Asprey welcomes Dr. Joseph Mercola to the Bulletproof Radio, on epsisode #398 to explore the expanding field of red light therapy, aka Photo-Bio-Modulation,  and how it’s helping scientists heal and repair the environmental destruction caused to the human body daily.

Go on, have a listen!

 

 

 

 

Using Radiation To Lose Fat, Repair Mitochondria & Defend Against Cancer – Dr. Joseph Mercola

Using Radiation To Lose Fat, Repair Mitochondria & Defend Against Cancer – Dr. Joseph Mercola

The Eyekandi team are Photo-Bio-Modulation and Red Light Therapy enthusiasts who take the bulletproof lifestyle, health and fitness seriously. Get in touch with us if you’re on the same path! We’d love to share notes and experiences…

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Red Light Therapy Health Benefits and How to Get It

Still wondering about the Red Light Therapy phenomenon?

KEEP READING…

As seen on the Bulletproof Blog, Red light therapy, also known as photo-bio-modulation (PBM), has been around for around 40 years – ever since the invention of lasers.

“Red light therapy uses certain wavelengths of light to restore, repair, and protect tissue that is either injured, degenerating, or at risk of dying. While varying wavelengths affect the body differently, as far as healing with red light is concerned, the most effective wavelengths range from 630-670 and 810-880.”

But this is how it really works…

The PBM wavelengths affect bodily cells on a biochemical level by increasing mitochondrial function. This is the ability to produce energy in the cells. The more that the cells can produce energy, the better the body can function. When red light wavelengths are used on the skin’s surface, they penetrate 8-10 millimetres deep into the skin. So depending upon where the red light is used (head or knee, for instance), all of the surrounding skin layers, blood vessels, lymph pathways, nerves, and even hair follicles are affected.

Mr Dave Asprey of Bulletproof Radio Health Benefits of Red Light Therapy and How to Get It

Mr Dave Asprey of Bulletproof Radio
Health Benefits of Red Light Therapy and How to Get It

The Benefits of Red Light Therapy (PBM)

Red light therapy works from the inside-out to enhance and increase mitochondrial function in cells. Therefore this, leads to several skin benefits. Red light reduces skin inflammation, smooths skin tone, repairs sun damage, fades scars and stretch marks, and even builds collagen in the skin which in turn reduces wrinkles. It also heals wounds and can prevent recurring cold sores or herpes simplex (some of us were burdened). PBM works on the lymphatic system to improve your body’s detoxification abilities by increasing blood flow. It may even stimulate hair growth in your hair follicles (check it out ladies!).

Still interested?

See the original post on the Bulletproof Blog and see the informative video clip they posted!

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Photo – Bio – Modulation: Low Level Light Therapy

Low Level Light Therapy

Lasers or as we sometime call it low laser light therapy (LLLT) are instrumental in the stem cell field. Pablo Rosada, of the Institute of Regenerative Medicine in the USA has been using them for a number of years. Light therapy has many profound effects. It seems to have an effect on the production of Exosomes, it seems to activate what are called senescent cells. It also seems to activate Very Small Embryonic Like Stem Cells.

Lasers and light have a profound effect on many aspects of the cell. Light therapy goes down to the basics of cell biology. What we now know is that the mitochondria which are the powerhouses of the cells have photoreceptors. In light therapy there is absorption of photons in a portion of the mitochondria cells. This has a direct effect on the cellular electron respiratory transport chain. This involves the Krebs cycle which brings us back to biochemistry days.

ATP

The result in the improvement in the electron transport chain is greater production of ATP. ATP is the essential energy of most cells. If cells are exposed to more energy than they will typically be more efficient at doing their job. LLLT seems to paradoxically increase reactive oxygen species (ROS) in healthy tissue but most importantly it decreases ROS in those tissues which suffer from oxidative stress. So we have little effect adverse effects on normal cells from ROS but a significant positive effect on ROS in diseased tissue. The use of LLLT in patients involves mainly red and near infrared (NIR). The wavelength of this light is between 600-950 nm.

Photo-Bio-Modulation

Image courtesy of the Institute of Regenerative Medicine

Low level light therapy have many profound effects on the cells. It appears that all genes from the antioxidant related category and genes related to energy metabolism and the respiratory chain were up regulated. It is thought that low level light therapy stimulates cell growth by influencing both directly and indirectly related to DNA synthesis and repair and cell metabolism. Stem cells are finicky enough. Anything we can do to nudge them along is so important. There is definitely more to come on this subject.

The team at Eyekandi are intrigued by LLLT, mitochondria, stem cell regeneration, and infrared light healing. Get in touch with us to share some insight, knowledge and ideas over a Bulletproof Coffee – We’d love to hear from you!

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Dottir at Formland: Interior and Design Exhibition Denmark

Dottir, our long time partners in ceramic design and manufacture, will be featured at the infamous FORMLAND exhibition next year.

Formland Spring, the most inspiring Nordic Interior and Design Fair, is set to take place between Feb 1 – 4 2018 in Denmark.

Formland is a professional trade fair, where Danish designs are all gathered in one place at the same time.

Come and get inspired.

Dottir products featured at the Formland Fair

Dottir products featured at the Formland Fair

“The creative thinking behind all DOTTIR products are nurtured by the contrasts of Nordic living, with its dark cold winters and bright warm summer nights, it’s deep silent lakes and strong ocean streams.
All products express this arabesque of sweet wildness which gives a versatile and creative expression. We are in contrast to the minimalistic Nordic expression and see our selves as front runners for the next Nordic Design movement. In short. Less is a bore.”

 

2018 is going to be a big year.

 

We, at Eyekandi, partner up with like-minded people who want to ‘get things made’. Our partner comes up with the ideas, and we help with the design and manufacturing.

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Color Matching Light Box, by Eyekandi

Check out this super cool machine we have made to check and compare textile and garment colors! It is our Color Matching Light Box.

Eyekandi engineers and developers see what the NEED is and create out of this world products and technology to our clients spec!

The lights used in this box vary from international standard daylight, to European and Japanese shop light, to an ultraviolet light source to USA shop light source to just name a few. The kelvins of the light (temperature) range from 2700K to 6500K!

Eyekandi: Joyce assessing colors with the Color Matching Light Box

Eyekandi: Joyce and Cindy assessing fabrics with the Color Matching Light Box

Color Matching Light Box: assessing the color of our BBHugMe fabrics

Color Matching Light Box: assessing our BBHugMe fabrics

In the picture you will see Joyce and Cindy of Eyekandi, using the Color Matching Light Box to assess the various colors of the textile and fabric products that come out of the Eyekandi supply-chain.

“We get things made”, and we’re up for your challenge.

 Contact our team of experts to get anything your heart desires, made.

 

 

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